188569-21-3

Upstream product

• 4982-08-5 1-hydroxy-3-phenylpropan-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 185396-37-6 (R)-2-amino-3-hydroxy-2-benzylpropionic acid 
• 186904-43-8 (S)-2-tert-Butoxycarbonylamino-3-methyl-butyric acid 2-oxo-3-phenyl-propyl ester 
• 188569-20-2 (S)-3-Benzyl-5-isopropyl-6-oxo-3,6-dihydro-2H-[1,4]oxazine-3-carbonitrile 
• 186904-45-0 (3S,5S)-3-Benzyl-5-isopropyl-6-oxo-morpholine-3-carbonitrile 

Downstream Products

• 833484-36-9 (3-benzyl-2-oxo-oxetan-3-yl)-carbamic acid tert-butyl ester 
• 1384954-86-2 C₁₉H₂₈N₂O₄ 
• 1384954-98-6 C₁₉H₂₈N₂O₄S 
• 1384954-94-2 C₁₉H₂₈N₂O₅ 
• 1384954-90-8 C₂₀H₃₀N₂O₄ 
• 872216-87-0 N-Boc-(R)-α-benzylserine β-lactone 
• 134234-61-0 (+)-α-hydroxymethylaspartic acid 

Relevant academic research and scientific papers

Lipase-catalyzed desymmetrization of quaternary carbon-containing 1,3-propanediols: A new entry to the asymmetric synthesis of α-substituted serine analogues

A new approach to the asymmetric synthesis of α-substituted serine analogues was developed. The method utilizes a lipase-catalyzed esterification desymmetrization protocol. In the presence of PPL, a series of benzyl-substituted quaternary 2-nitropropane-1

A convenient transformation of α-alkylserines into α-halogenomethyl-α-alkylglycines

An efficient and facile synthesis of N-Boc-α-chloromethyl- and α-bromomethyl-α-alkylglycines is reported that involves cyclization of N-Boc-α-alkylserines to the corresponding β-lactones under Mitsunobu reaction conditions, followed by ring opening with anhydrous MgCl2 or MgBr2.

Asymmetric Syntheses of Both Enantiomers of α-Benzylserine and α-Carboxymethylserine

Both enantiomers of α-benzyl and α-carboxymethyl serines (1, 2) were efficiently synthesized starting with the known phenyl acetol via an intramolecular asymmetric Strecker synthesis.