872216-87-0Relevant academic research and scientific papers
A convenient route to optically pure α-alkyl-β-(sec-amino) alanines
Olma,Lasota,Kudaj
experimental part, p. 2525 - 2528 (2012/07/27)
The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protein amino acids.
Transformation of α-hydroxymethylamino acids into α-mercaptomethylamino acids (α-alkylcysteines)
Olma
, p. 831 - 835 (2007/10/03)
N-Boc-α-alkylserines (α-hydroxymethylamino acids) undergo a cyclization reaction without racemization to N-Boc-α-alkylserine-β- lactones in 90-98% yield using Mitsunobu conditions (Ph3P, diethyl azodicarboxylate). Treatment of the corresponding
