18857-02-8

Basic information

• Product Name: 3-methoxybut-1-yne
• CAS NO: 18857-02-8
• Molecular Formula: C₅H₈O
• Molecular Weight: 84.1164
• Mol File: 18857-02-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 79.7°C at 760 mmHg
• Density: 0.828g/cm³
• Vapor Pressure: 97.3mmHg at 25°C
• Refractive Index: 1.402
• CAS DataBase Reference: 3-methoxybut-1-yne(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxybut-1-yne(18857-02-8)
• EPA Substance Registry System: 3-methoxybut-1-yne(18857-02-8)

Safety Data

• Hazardous Substances Data: 18857-02-8(Hazardous Substances Data)

Upstream product

• 2028-63-9 but-3-yn-2-ol 
• 77-78-1 dimethyl sulfate 
• 75-18-3 dimethylsulfide 
• 136157-90-9 3,3-dimethoxy-1-butyne 

Downstream Products

• 17742-05-1 3-methoxybutan-2-one 
• 330558-57-1 methyl 3-(4-fluorophenyl)-1,2-oxazole-5-carboxylate 
• 1081-30-7 3-phenyl-isoxazole-5-carboxylic acid methyl ester 
• 1262034-09-2 C₁₆H₂₁NO₃ 
• 89358-54-3 4-diphenylphosphinoyl-2-methoxy-3-methylhexan-3-ol 
• 69930-76-3 2-diphenylphosphinoyl-4-methoxy-3-methylpentan-3-ol 
• 344871-55-2 1-diphenylphosphinoyl-3-methoxy-2-methylbutan-2-ol 
• 67280-39-1 N-(4-methoxy-2-pentynyl)-N-methylbenzylamine 
• 51233-49-9 4-Methoxy-3-methyl-1-phenyl-pent-1-yn-3-ol 

Relevant articles and documents

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HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Resolution of carboxylic acids using copper(I)-promoted removal of propargylic esters under neutral conditions

A method for the optical resolution of carboxylic acids is described. Condensation of racemic carboxylic acids with chiral terminal propargyl alcohols gave separable diastereomeric esters. Chromatographic separation followed by heating the individual diastereomers in methanol with catalytic copper(I) halide regenerated the carboxylic acids in good yields and in enantiomeric ratios of ?94%. This method is particularly useful for the resolution of carboxylic acids that are incompatible with conventional ester hydrolysis.