1081-30-7

Basic information

• Product Name: 5-Isoxazolecarboxylic acid, 3-phenyl-, methyl ester
• CAS NO: 1081-30-7
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.197
• Mol File: 1081-30-7.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 5-Isoxazolecarboxylic acid, 3-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Isoxazolecarboxylic acid, 3-phenyl-, methyl ester(1081-30-7)
• EPA Substance Registry System: 5-Isoxazolecarboxylic acid, 3-phenyl-, methyl ester(1081-30-7)

Safety Data

• Hazardous Substances Data: 1081-30-7(Hazardous Substances Data)

Upstream product

• 922-67-8 propynoic acid methyl ester 
• 698-16-8 benzohydroximoyl chloride 
• 932-90-1 Benzaldoxime 
• 14442-12-7 3-phenylisoxazole-5-carboxylic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 67-56-1 methanol 
• 932-90-1 syn-benzaldehyde oxime 
• 18857-02-8 3-methoxybut-1-yne 
• 1729-67-5 Methyl 2,3-dibromopropionate 
• 81745-44-0 benzohydroximoyl chloride 
• 75025-16-0 3-Phenyl-isoxazole-5-carboxylic acid benzyl ester 
• 873-67-6 benzonitrile oxide 
• 1821-34-7 N-chlorobenzamide 
• 4519-46-4 methyl 2-bromoacrylate 

Downstream Products

• 103912-53-4 9-oxo-3,6-diphenyl-7-phenylimino-1-oxa-2,6,8-triazaspiro<4.4>non-2-ene 
• 103912-65-8 9-oxo-8-dimethyl-3,6-diphenyl-7-phenylimino-1-oxa-2,6,8-triazaspiro<4.4>non-2-ene 
• 169272-00-8 3-Phenyl-isoxazole-5-carboxylic acid dimethylamide 
• 14442-12-7 3-phenylisoxazole-5-carboxylic acid 

Relevant articles and documents

Isoxazoles from 1,1-disubstituted bromoalkenes

The regioselective synthesis of 3,5-disubstituted isoxazoles was achieved through the 1,3-dipolar cycloaddition of nitrile oxides with 1,1-disubstituted bromoalkenes. The substituted bromoalkenes function as alkyne synthons which were used to construct 5,

Methyl 3-Substituted-isoxazole-5- Carboxylates syntheses on solid supports via wang resin-bound 2,3-dibromopropionate

A novel Wang resin-bound 2,3-dibromopropionate reagent has been developed and used as a potential dipolarophile for the facile preparation of methyl 3-substituted-isoxazole-5-carboxylates through triethylamine, promoting a sequence of reactions involving the in situ generation of 2-bromoacrylate resin and nitrile oxide, regioselective 1,3-dipolar cycloaddition, and loss of hydrogen bromide in one pot, and then cleavage from the resin with sodium methoxide. The advantages of this method include simple operation and mild conditions with good yield and high purity of the products. Copyright

METHODS OF TREATING PULMONARY DISEASES AND DISORDERS

The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.

ISOXAZOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

The invention relates to a compound of Formula (I) and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula (I) or II to a patient in need thereof: Formula (I) and Formula (II). The invention relates to the use of substituted oxazole and substituted thiazole compounds in the treatment of cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases.