188577-14-2Relevant academic research and scientific papers
A new chiral disulfonamide ligand derived from α-amino acid for catalytic enantioselective cyclopropanation
Imai, Nobuyuki,Sakamoto, Katsumasa,Maeda, Masahiro,Kouge, Kazushi,Yoshizane, Kenji,Nokami, Junzo
, p. 1423 - 1426 (2007/10/03)
A new disulfonamide prepared from α-amino acid in five steps catalyzed cyclopropanation of allylic alcohols with Et2Zn and CH2I2 to afford the corresponding cyclopropylmethanols in moderate to good enantioselectivites. In particular, the reaction of cinnamyl alcohol in the presence of a chiral disulfonamide 1k afforded an excellent enantioselectivity (85% ee).
