188577-44-8

Upstream product

• 96-09-3 styrene oxide 
• 41661-47-6 piperidin-4-one 
• 41979-39-9 4-piperidone hydrochloride 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 188577-41-5 2-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-1-phenylethan-1-ol 

Downstream Products

• 1269606-80-5 2-(4-cyclopentylamino-piperidin-1-yl)-1-phenyl-ethanol 
• 1269606-11-2 Cyclopentyl-(1-{2-[4-(2-methoxy-ethyl)-piperazin-1-yl]-2-phenyl-ethyl}-piperidin-4-yl)-amine 

Relevant academic research and scientific papers

ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to arylamide derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit,of the voltage-gated calcium channel and the μ-opioid receptor, to processes of preparation of such c

Novel Ethanediamone Hepcidine Antagonists

The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

1,3-Dioxolanes of N-Substituted 4-Piperidones as Substrates for Dehydrogenations

The applicability of ketals was examined for masking the carbonyl group in N-tertiary 4-piperidones during the dehydrogenation using mercury-edta. Various 1,3-dioxolanes showed a different behaviour in dependence on the N-substituent. With simple aliphatic moieties mainly dehydrogenated but hydrolyzed products were received. These enaminones were also available from the dehydrogenations of the corresponding 4-piperidones. Similar applied to para-acyl-aromatic substituted derivatives but with less yields. Aromatic substituents bearing a neighbour group on ortho-position with participation gave rise to different oxidation products partially with preservation of the ketal structure.