188642-63-9Relevant academic research and scientific papers
An enantioselective route to pyrrolidines: Removal of the chiral template from homochiral pyrroloimidazoles
Jones, Raymond C.F.,Howard, Kevin J.,Snaith, John S.,Blake, Alexander J.,Li, Wang-Shei,Steel, Peter J.
experimental part, p. 8925 - 8936 (2011/12/02)
Two-step reductive removal of the chiral template from optically active pyrroloimidazoles, available from 1,3-dipolar cycloaddition of homochiral 4,5-dihydroimidazolium ylides, gives optically active substituted pyrrolidines. Selective manipulation of the substituents affords, e.g., naturally occurring and other optically active proline derivatives, and optically active pyrrolizidines and indolizidines.
A rapid assembly of homochiral 2,3,4-trisubstituted pyrrolidines
Jones, Raymond C. F.,Howard, Kevin J.,Snaith, John S.
, p. 1647 - 1650 (2007/10/03)
The intramolecular 1,3-dipolar cycloaddition of homochiral dihydroimidazolium ylides, generated in situ, is the key reaction in a sequence that rapidly affords optically active 2,3,4-trisubstituted pyrrolidines suitably functionalised for further elaboration.
