188642-72-0

Upstream product

• 13038-13-6 (E)-5-hydroxy-pent-2-enoic acid ethyl ester 
• 175792-71-9 (S)-1-benzyl-4-phenyl-4,5-dihydroimidazole 
• 188642-53-7 ethyl (E)-5-(bromoacetoxy)pent-2-enoate 

Downstream Products

• 188642-69-5 (3S,5S,6R,7R,7aS)-1-benzyl-5,7-bis(methoxymethyl)-6-(2-methoxyethyl)-3-phenylhexahydropyrrolo[1,2-a]imidazole 
• 188642-70-8 Benzyl-{(S)-2-[(2S,3R,4R)-3-(2-methoxy-ethyl)-2,4-bis-methoxymethyl-pyrrolidin-1-yl]-2-phenyl-ethyl}-amine 
• 188642-63-9 (4S,7R,8R,8aS)-2-benzyl-7-ethoxycarbonyl-8-(2-hydroxyethyl)-4-phenyloctahydropyrrolo[1,2-a]pyrazin-1-one 
• 188642-67-3 (3S,5S,6R,7R,7aS)-1-benzyl-5,7-bis(hydroxymethyl)-6-(2-hydroxyethyl)-3-phenylhexahydropyrrolo[1,2-a]imidazole 

Relevant academic research and scientific papers

A rapid assembly of homochiral 2,3,4-trisubstituted pyrrolidines

The intramolecular 1,3-dipolar cycloaddition of homochiral dihydroimidazolium ylides, generated in situ, is the key reaction in a sequence that rapidly affords optically active 2,3,4-trisubstituted pyrrolidines suitably functionalised for further elaboration.

Cycloaddition of homochiral dihydroimidazoles: A 1,3-dipolar cycloaddition route to optically active pyrrolo[1,2-a]imidazoles

N-Alkylation of optically active 1-benzyl-4-phenyl-4,5-dihydroimidazole with active alkyl halides and treatment of the so-formed 4,5-dihydroimidazolium ions with DBU in the presence of a range of electron-deficient alkene dipolarophiles, constitutes a 'on