188645-92-3Relevant articles and documents
Total Synthesis and Absolute Stereochemical Assignment of the Insecticidal Metabolites Yaequinolones J1 and J2
Vece, Vito,Jakkepally, Shashidhar,Hanessian, Stephen
, p. 4277 - 4280 (2018)
A highly stereocontrolled total synthesis of (-)-yaequinolone J1 and (+)-yaequinolone J2 was accomplished using an Evans auxiliary to establish a syn-diol unit in an acyclic appendage to a preformed benzopyran core bearing a homoprenyl group. The first to
HEPATITIS C INHIBITOR COMPOUNDS
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Page/Page column 54, (2011/06/23)
Compounds of Formula (I) wherein R1, R2, R3, R4 and R5 are defined herein, maintain good activity against NS3 proteases containing clinically relevant genotype 1a R155K and genotype 1b D168V resistance mutations. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.
