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Usage

Uses

Used in Organic Synthesis:
3-Aminocarbonylphenylboronic acid, pinacol ester is used as a versatile building block for the synthesis of various organic compounds. Its ability to react with a range of nucleophiles makes it an essential component in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Aminocarbonylphenylboronic acid, pinacol ester is utilized as a key intermediate in the development of new drugs. Its unique chemical properties facilitate the synthesis of bioactive molecules with potential therapeutic applications.
Used in Agrochemical Industry:
3-Aminocarbonylphenylboronic acid, pinacol ester is also employed in the agrochemical sector, where it serves as a precursor for the synthesis of agrochemicals, such as pesticides and herbicides, that are designed to protect crops and enhance agricultural productivity.
Used in Cancer Research and Treatment:
3-Aminocarbonylphenylboronic acid, pinacol ester has been studied for its potential applications in the treatment of cancer and other diseases. Its unique chemical structure allows for the development of targeted therapies that can selectively interact with cancer cells, offering a promising avenue for the advancement of cancer treatment strategies.

InChI:InChI=1/C13H18BNO3/c1-12(2)13(3,4)18-14(17-12)10-7-5-6-9(8-10)11(15)16/h5-8H,1-4H3,(H2,15,16)

Upstream product

• 55-21-0 benzamide 
• 73183-34-3 bis(pinacol)diborane 
• 22726-00-7 3-bromobenzamide 

Downstream Products

• 1401461-72-0 3-(7-(3,4,5-trimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzamide 
• 1402883-70-8 4′-((1R,2S)-2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)cyclopropyl)biphenyl-3-carboxamide hydrochloride 
• 1391924-89-2 3-(4-((dimethylcarbamoyl)methylamino)-6-morpholino-1,3,5-triazin-2-yl)benzamide 
• 1620055-36-8 3-(6-amino-2-(2-(3,5-difluorophenyl)-1-(2-(5-fluoro-1H-indol-3-yl)acetamido)ethyl)pyridin-3-yl)benzamide 
• 1356924-01-0 2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxazolo[4,5-b]pyrazine 
• 252578-40-8 4-(benzyloxy)-3-bromophenol 
• 1357091-70-3 [4-benzyloxy-3-(3-carbamoylphenyl)phenyl]-N-cyclohexylcarbamate 
• 1415694-95-9 (S)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide 2,2,2-trifluoroacetate 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors

Apoptosis signal-regulating kinase 1 (ASK1, MAP3K5), a member of the mitogen-activated protein kinase (MAPK) signaling pathway, is involved in cell survival, differentiation, stress response, and apoptosis. ASK1 kinase inhibition has emerged as a promisin

Amide Effects in C?H Activation: Noncovalent Interactions with L-Shaped Ligand for meta Borylation of Aromatic Amides

A new concept for the meta-selective borylation of aromatic amides is described. It has been demonstrated that while esters gave para borylations, amides lead to meta borylations. For achieving high meta selectivity, an L-shaped bifunctional ligand has been employed and engages in an O???K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for meta C?H activation/borylation.

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo

In the present study, a series of m-(4-morpholinoquinazolin-2-yl)benzamides were designed, synthesized and characterized. The antiproliferative activities of the synthesized compounds were evaluated against two human cell lines (HCT-116 and MCF-7). Compounds with IC50 values below 4 μM were further evaluated against U-87 MG and A549 cell lines. Among these evaluated compounds, compound T10 displayed a remarkable antiproliferative effect in vitro. The hoechst staining assay showed that compound T10 caused morphological changes. The cell cycle and apoptosis assay further indicated that compound T10 can arrest HCT-116 cells in G2/M and G0/G1 phase and induce apoptosis. PI3K enzyme assays indicated that compounds T7 and T10 selectively inhibit PI3K±. A Western bolt assay further suggested that compound T10 can block the PI3K/Akt/mTOR pathway. Moreover, compound T10 inhibited tumor growth on a mice S180 homograft model. These findings directly identify m-(4-morpholinoquinazolin-2-yl)benzamide derivatives as novel anticancer agents.