252578-40-8

Usage

Uses

Used in Organic Synthesis:
4-Benzyloxy-3-bromo-phenol is used as a building block for the synthesis of various compounds, contributing to the development of new organic molecules with potential applications in various fields.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-Benzyloxy-3-bromo-phenol is utilized as an intermediate for the synthesis of drugs and other biologically active molecules, aiding in the discovery and development of novel therapeutic agents.
Used in Agrochemical Manufacturing:
4-Benzyloxy-3-bromo-phenol is employed as an intermediate in the production of agrochemicals, playing a role in the creation of substances that help protect crops and enhance agricultural productivity.
Used in Pharmaceutical Manufacturing:
This chemical compound is also used in the manufacturing of pharmaceuticals, serving as a key intermediate in the synthesis of various medications, thereby contributing to the advancement of healthcare.
It is crucial to handle 4-Benzyloxy-3-bromo-phenol with care due to its potential hazards if not properly managed and stored, ensuring safety in its applications across different industries.

Upstream product

• 583-69-7 2-bromobenzene-1,4-diol 
• 100-39-0 benzyl bromide 
• 1426068-23-6 (4-benzyloxyphenyl)-N-cyclohexylcarbamate 
• 103-16-2 4-Benzyloxyphenol 
• 1426068-24-7 C₂₀H₂₂BrNO₃ 
• 1426068-27-0 3-(1,3,2-benzodioxaborol-2-yl)benzamide 
• 1426068-26-9 3-(1,3,2-dioxaborolan-2-yl)benzamide 
• 188665-74-9 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 351422-73-6 (3-(aminocarbonyl)phenyl)boronic acid 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 100-44-7 benzyl chloride 
• 69455-12-5 4-benzyloxy-3-bromobenzaldehyde 

Downstream Products

• 536974-68-2 2-(4-benzyloxy-3-bromophenoxy)ethanol 
• 775335-97-2 5-(benzyloxy)-4-bromo-2-hydroxybenzaldehyde 
• 1357091-70-3 [4-benzyloxy-3-(3-carbamoylphenyl)phenyl]-N-cyclohexylcarbamate 
• 1357160-72-5 URB₉₃₇ 
• 1446086-57-2 3-(2-benzyloxy-5-hydroxyphenyl)benzaldehyde 
• 1446086-60-7 cyclohexylcarbamic acid 3′-acetyl-6-benzyloxybiphenyl-3-yl ester 
• 1446086-59-4 cyclohexylcarbamic acid 6-benzyloxy-3′-formylbiphenyl-3-yl ester 

Relevant academic research and scientific papers

Development of a Multigram synthesis of URB937, a peripherally restricted FAAH inhibitor

A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield.

PERIPHERALLY RESTRICTED FAAH INHIBITORS

Peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH) are provided. The compounds can suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). Despite their relative inability to access brain and spinal cord, the compounds attenuate behavioral responses indicative of persistent pain in rodent models of inflammation and peripheral nerve injury, and suppresses noxious stimulus-evoked neuronal activation in spinal cord regions implicated in nociceptive processing. CBi receptor blockade prevents these effects. Accordingly, the invention also provides methods, and pharmaceutical compositions for treating conditions in which the inhibition of peripheral FAAH would be of benefit. The compounds of the invention are according to the formula (I): in which R1 is a polar group. In some embodiments, R1 is selected from the group consisting of hydroxy and the physiologically hydro lysable esters thereof. R2 and R3 are independently selected from the group consisting of hydrogen and substituted or unsubstituted hydrocarbyl; each R4 is independently selected from the group consisting of halogen and substituted or unsubstituted hydrocarbyl and n is an integer from 0 to 4; each R5 is independently selected from the group consisting of halo and substituted or unsubstituted hydrocarbyl and m is an integer from 0 to 3; and R6 is substituted or unsubstituted cyclohexyl; and the pharmaceutically acceptable salts thereof.

BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R1, R2, R3, and R4 are as described in specification.

CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (I). Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.