252578-40-8

Basic information

• Product Name: 4-Benzyloxy-3-bromo-phenol
• Synonyms: 4-Benzyloxy-3-bromo-phenol
• CAS NO: 252578-40-8
• Molecular Formula: C₁₃H₁₁BrO₂
• Molecular Weight: 279.13
• Mol File: 252578-40-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 398.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.478±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.36±0.20(Predicted)
• CAS DataBase Reference: 4-Benzyloxy-3-bromo-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyloxy-3-bromo-phenol(252578-40-8)
• EPA Substance Registry System: 4-Benzyloxy-3-bromo-phenol(252578-40-8)

Safety Data

• Hazardous Substances Data: 252578-40-8(Hazardous Substances Data)

Usage

General Description

4-Benzyloxy-3-bromo-phenol, also known as 3-Bromo-4-hydroxybenzyl alcohol, is a chemical compound with the molecular formula C13H11BrO2. It is a phenolic compound with a benzene ring substituted with a hydroxyl group and a bromine atom. This chemical is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various compounds. It is also used as an intermediate in the manufacturing of agrochemicals and pharmaceuticals. 4-Benzyloxy-3-bromo-phenol has potential applications in the development of drugs and other biologically active molecules. However, it is important to handle this chemical with caution as it may pose hazards if not properly handled and stored.

Upstream product

• 1426068-23-6 (4-benzyloxyphenyl)-N-cyclohexylcarbamate 
• 103-16-2 4-Benzyloxyphenol 
• 1426068-24-7 C₂₀H₂₂BrNO₃ 
• 1426068-27-0 3-(1,3,2-benzodioxaborol-2-yl)benzamide 
• 1426068-26-9 3-(1,3,2-dioxaborolan-2-yl)benzamide 
• 188665-74-9 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 351422-73-6 (3-(aminocarbonyl)phenyl)boronic acid 
• 583-69-7 2-bromobenzene-1,4-diol 
• 100-39-0 benzyl bromide 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 100-44-7 benzyl chloride 
• 69455-12-5 4-benzyloxy-3-bromobenzaldehyde 

Downstream Products

• 536974-68-2 2-(4-benzyloxy-3-bromophenoxy)ethanol 
• 775335-97-2 5-(benzyloxy)-4-bromo-2-hydroxybenzaldehyde 
• 1357091-70-3 [4-benzyloxy-3-(3-carbamoylphenyl)phenyl]-N-cyclohexylcarbamate 
• 1357160-72-5 URB₉₃₇ 
• 1446086-57-2 3-(2-benzyloxy-5-hydroxyphenyl)benzaldehyde 
• 1446086-60-7 cyclohexylcarbamic acid 3′-acetyl-6-benzyloxybiphenyl-3-yl ester 
• 1446086-59-4 cyclohexylcarbamic acid 6-benzyloxy-3′-formylbiphenyl-3-yl ester 

Relevant articles and documents

Development of a Multigram synthesis of URB937, a peripherally restricted FAAH inhibitor

A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield.

BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R1, R2, R3, and R4 are as described in specification.

Compound

There is provided a compound of Formula I 1 wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.