188686-98-8Relevant academic research and scientific papers
Efficient regioselective synthesis of 4- and 5-substituted isoxazoles under thermal and microwave conditions
Lasri, Jamal,Mukhopadhyay, Suman,Charmier, M. Adilia Januario
experimental part, p. 1385 - 1389 (2009/04/10)
(Chemical Equation Presented) The [2+3] cycloaddition reaction between nitrile oxides 2 and the captodative olefins 1 or the methyl crotonate derivatives 4 is regioselective and leads to the formation of the 5-substituted amino-isoxazole 3 or the 4-substi
An expedient synthesis of (±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide via a 3-bromoisoxazole intermediate
Hanson, Robert N.,Mohamed, Fand A.
, p. 345 - 348 (2007/10/03)
The excitatory, amino acid ± 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide was prepared in gram quantities in a 3.3% overall yield from methylbut 2-ynoate. The key step was the facile preparation of methyl 3-bromo-5-methylisoxazole-4-carboxylate.
