188712-85-8Relevant academic research and scientific papers
Synthesis of functionalised fluorescent dyes and their coupling to amines and amino acids
Briggs, Mark S. J.,Bruce, Ian,Miller, James N.,Moody, Christopher J.,Simmonds, Adrian C.,Swann, Elizabeth
, p. 1051 - 1058 (2007/10/03)
A series of novel functionalised benzophenoxazinones, analogues of Nile Red, is prepared and their fluorescence properties evaluated. The ring system is prepared by reaction of 5-diethylamino-2-nitrosophenol with 1,6-dihydroxynaphthalene followed by alkylation of the 2-hydroxy group with 6-bromohexanoic acid derivatives. Subsequent ester cleavage under a variety of conditions gives the acid 6. Replacement of the 9-diethylamino group with the N-ethyl-(3-sulfonylpropyl)amino group is carried out to increase water solubility and the resulting dye 14 has similar fluorescence properties. The acid 6 is coupled to a range of amino compounds.
