188715-40-4Relevant academic research and scientific papers
Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases
Yang, Peng-Yu,Wu, Hao,Lee, Mei Yin,Xu, Ashley,Srinivasan, Rajavel,Yao, Shao Q.
supporting information; experimental part, p. 1881 - 1884 (2009/04/18)
An efficient strategy for the solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases is described. The method is highlighted by its compatibility with readily available building blocks, as well as its ability to accommodate differ
Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
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Page/Page column 23, (2008/06/13)
The compounds having the general structure of formula (I) wherein the symbols, indices and substituents have the following meaning if R2=OH and R3=H then R1=H, CN, NO2, CF3, F, Cl, Br, I, CH3 or if R3=OH and R2=H then R1=H, CN, NO2, CF3, F, Cl, Br, I, CH3, Et, n-Pr, i-Pr, n-Bu, i-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl or if R3=OH and R1=H then R2=H, CN, NO2, CF3, F, Cl, Br, I, CH3, Et, n-Pr, i-Pr, n-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl then X is e.g. ???with R4 being H, CH3, CH2CH3 or or ???and Y being or and the pharmaceutically acceptable salts, esters or amides and prodrugs of the above identified compounds of formula (I). The compounds are applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.
beta-sheet mimetics and composition and methods relating thereto
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Page 17; 18, (2010/11/30)
Compounds having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein A, A′, B, X, Y, R2, R3, R4 and R5 are as defined herein. Such compounds have utility over
