188718-67-4Relevant academic research and scientific papers
Synthesis of 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]-quinazolines. Inhibitors of Candida albicans dihydrofolate reductase as potential antifungal agents
Chan,Hong,Kuyper,Jones,Baccanari,Tansik,Boytos,Rudolph,Brown
, p. 145 - 151 (2007/10/03)
A series of novel 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]quinazolines were synthesized starting from 6-amino-5-cyanoquinoline (4). These compounds inhibited Candida albicans dihydrofolate reductase with K(i) values of ≤ 0.60 nM. One analogue exhibite
