106230-15-3

Upstream product

• 100-63-0 phenylhydrazine 
• 17571-17-4 4-benzoyl-5-phenyl-furan-2,3-dione 
• 59-88-1 phenylhydrazine hydrochloride 
• 622-73-1 4-methoxybenzaldehydephenylhydrazone 
• 588-64-7 benzaldehyde phenylhydrazone 
• 574-61-8 benzophenone N-phenylhydrazone 
• 583-11-9 N-(1-phenylethylidene)phenylhydrazine 

Downstream Products

• 63514-83-0 4-Benzoyl-1,5-diphenyl-pyrazol-3-carbonsaeureethylester 
• 63514-98-7 2,3,4-triphenyl-2H-pyrazolo<3,4-d>pyridazin-7(6H)-one 
• 188724-74-5 4-benzoyl-1,5-diphenyl-1H-3-pyrazole carboxylic acid chloride 
• 1032065-34-1 2,3,4-triphenylpyrazolo[4,3-d]oxazin-7(2H)-one 
• 188724-65-4 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid benzyl ester 
• 188724-68-7 N-(4-methylphenyl)-4-benzoyl-1,5-diphenyl-1H-3-pyrazolecarboxamide 
• 188724-64-3 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid i-pentyl ester 
• 188724-66-5 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid phenyl ester 
• 188724-67-6 4-benzoyl-1,5-diphenylpyrazole-3-carboxylic amide 
• 63515-00-4 2,3,4,6-tetraphenyl-2H-pyrazolo<3,4-d>pyridazin-7(6H)-one 

Relevant academic research and scientific papers

Synthesis and reactions of 4-benzoyl-1,5-diaryl-1h-pyrazole-3-carbonyl chlorides with various semi- and thiosemicarbazides

(Chemical Equation Presented) The 1H-pyrazole-3-carboxylic acids 2 were converted via reactions of their acid chlorides 3 with some semi- and thiosemicarbazide derivatives into the corresponding new phenylsemi- and thiosemicarbazides 4a-e, 6, 5-(pyrazol-3-yl)-4H-1,2,4-triazol-3-thiones 5a,b, and 2-(pyrazol-3-yl)-1,3,4-thiadiazol 7 derivatives, in good yields (45-97%, respectively). The reactions of 4a,c,e with Lawesson reagent lead to the products 6 and 7 formation. The structures of these newly synthesized compounds were determined. from the IR, 1H- and 13C-NMR spectroscopic data and elemental analyses.

Microwave-assisted studies on the reactions of the 4-Benzoyl-5-phenyl- 2,3-dihydro-2,3-furandione and derivatives

Varieties of heterocyclic compounds were prepared in good yield from 4-benzoyl-5-phenyl-2,3-dihydro-2,3- furandione under microwave irradiation conditions. The reaction revealed much shorter reaction times with comparable yields comparison to the corresponding thermal conditions.

Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide

Some novel pyrazole-NO hybrid molecules 5a-e, 6, 8 and 10 were prepared through binding of the pyrazole-3-carboxylic acid derivatives with nitric oxide donor moiety like oxime or nitrate ester. The prepared compounds were evaluated for nitric oxide release, antibacterial and anti-inflammatory activities. The organic nitrate 10 exhibited the highest percentage of NO release using Griess diazotization method. Some of the prepared compounds exhibited remarkable antibacterial activity against Escherichia coli C-600, Pseudomonas aeruginosa, Bacillus subitilis and Staphylococcus aureus NCTC 6571 compared to ciprofloxacin. Most of the tested compounds showed significant anti-inflammatory activity compared to indomethacine using carrageenan induced paw edema method. In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates.

Experimental and Theoretical Studies on the Functionalization Reactions of 4-Benzoyl-1,5-Diphenyl-1H-Pyrazole-3-Carboxylic Acid and Acid Chloride with 2,3-Diaminopyridine

The 1H-pyrazole-3-carboxylic acid 2 was converted in good yield (69 percent) into the corresponding 1H-pyrazole-3-carboxamide 5 via reaction of the acid chloride 3 with 2,3-diaminopyridine (4). A different product, the 3H-imidazo[4,5-b]pyridine derivative 6, was formed from the reaction of 3 with 4 and base in benzene for 5 hours. The structures of the synthesized compounds were determined spectroscopically. The mechanism of the reaction between 3 and 4 was examined theoretically.