188727-63-1Relevant academic research and scientific papers
Synthesis and structural optimization of 7-(3,3-disubstituted-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8 -methoxy-4-oxo-3-quinolinecarboxylic acids as antibacterial agents
Kitani, Hiroyuki,Kuroda, Tsuyoshi,Moriguchi, Akihiko,Ao, Hideki,Hirayama, Fumihiro,Ikeda, Yoshifumi,Kawakita, Takeshi
, p. 515 - 520 (2007/10/03)
A series of the titled compounds were synthesized and tested for antibacterial activities in comparison with typical fluoroquinolones. (S)-3-Aminomethyl-3-fluoromethyl derivative (Y-688) was confirmed to be optimal because of being most active especially against Gram-positive bacteria including fluoroquinolone-resistant strains and showing high photostability.
