162686-34-2Relevant academic research and scientific papers
Synthesis and structural optimization of 7-(3,3-disubstituted-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8 -methoxy-4-oxo-3-quinolinecarboxylic acids as antibacterial agents
Kitani, Hiroyuki,Kuroda, Tsuyoshi,Moriguchi, Akihiko,Ao, Hideki,Hirayama, Fumihiro,Ikeda, Yoshifumi,Kawakita, Takeshi
, p. 515 - 520 (2007/10/03)
A series of the titled compounds were synthesized and tested for antibacterial activities in comparison with typical fluoroquinolones. (S)-3-Aminomethyl-3-fluoromethyl derivative (Y-688) was confirmed to be optimal because of being most active especially against Gram-positive bacteria including fluoroquinolone-resistant strains and showing high photostability.
8-methoxy-quinolonecarboxylic acid derivatives
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, (2008/06/13)
8-Methoxy-quinolonecarboxylic acid derivatives of the formula STR1 wherein R1 is a hydrogen atom, a lower alkyl, a phenylalkyl or an ester residue hydrolyzable in the living body, R2 is a hydrogen atom or methyl and n is an integer o
