188729-96-6Relevant articles and documents
Radical-induced opening of trisubstituted epoxides: Application in the synthesis of C1-C12 segment of epothilones
Chakraborty,Dutta
, p. 101 - 104 (2007/10/03)
Diastereo- and regioselective opening of a trisubstituted epoxy ketone at the more substituted carbon using samarium(II) iodide presents an alternate approach to the C5-C7 aldol moiety with β-hydroxyketo framework in the stereoselective synthesis of C1-C12 segment of epothilones.
Total synthesis of epothilone A: The macrolactonization approach
Nicolaou,Sarabia,Ninkovic,Yang
, p. 525 - 527 (2007/10/03)
This highly convergent and practical total synthesis of the antitumor agent epothilone A uses a macrolactonization as the key step. The strategy may provide access to a variety of epothilones desirable for biological screening.