188744-95-8Relevant articles and documents
Synthesis of transition state inhibitors for N-riboside hydrolases and transferases
Furneaux, Richard H.,Limberg, Gerrit,Tyler, Peter C.,Schramm, Vern L.
, p. 2915 - 2930 (2007/10/03)
A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.