188758-83-0Relevant academic research and scientific papers
Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4- (alkylamino)-5-nitroquinoline bioreductive drugs
Siim, Bronwyn G.,Atwell, Graham J.,Anderson, Robert F.,Wardman, Peter,Pullen, Susan M.,Wilson, William R.,Denny, William A.
, p. 1381 - 1390 (2007/10/03)
Studies have shown that 4-(alkylamino)-5-nitroquinolines possess high selectivity (20-60-fold) for hypoxic tumor cells in vitro, but are not active as hypoxia-selective cytotoxins (HSCs) in vivo. The compounds show inadequate rates of extravascular diffus
