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Usage

Uses

Used in Agricultural Industry:
N,N-diMethyl-N'-(thiazol-2-yl)forMaMidine is used as an insecticide for controlling a variety of pests that can cause significant damage to crops. Its application helps protect crops such as corn, soybeans, and cotton from harmful insects like aphids, beetles, and thrips, ensuring higher crop yields and quality.
However, due to concerns about its potential impact on pollinators and the environment, the use of N,N-diMethyl-N'-(thiazol-2-yl)forMaMidine is subject to regulations and monitoring in various regions. Some areas have restricted or banned its use to mitigate potential risks to pollinators and the environment.

Upstream product

• 96-50-4 2-thiazolylamine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 25602-39-5 N-(thiazol-2-yl)formamide 
• 68-12-2 N,N-dimethyl-formamide 
• 124-40-3 dimethyl amine 
• 255842-15-0 2-Thiazolyl isocyanide 

Downstream Products

• 30006-91-8 3-phenyl-thiazolo[3,2-a][1,3,5]triazine-2,4-dione 

Relevant academic research and scientific papers

3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to 3-aza-bicyclo[3.1.0]hexane derivatives of formula (I) wherein A, B, n, X, and R1 are as described in the description, and salts thereof, and their use as orexin receptor antagonists.

2-CYCLOPROPYL-THIAZOLE DERIVATIVES

The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as med

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

2-CYCLOPROPYL-THIAZOLE DERIVATIVES

The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

Synthesis and reactions of aromatic and heterocyclic isocyanides

Reactions of halo-and nitroanilines with dichlorocarbene resulted in formation of the corresponding isocyanides in poor yields. Better results are obtained by treatment with phosphoryl chloride of formanilides having the same substituents. The latter procedure was used to prepare previously inaccessible derivatives of 2-pyridyl, 2-thiazolyl, and 1,3,4-thiadiazol-2-yl isocyanides. To prevent polymerization, the isocyanides were isolated as complexes with copper(I) bromide which can be decomposed with aqueous potassium cyanide to release free isocyanides. Aryl and heteryl isocyanides reacted with such nucleophiles as water and dimethylamine under mild conditions.

C-Phosphorylated N2-2-thiazolylformamidines

C-Phosphorylation of 2-thiazolylformamidines by phosphorus tribromide was studied. It was shown that the 1,3-diazabut-1-enyl (formamidine) substituent can be used as both an activating and protective group. 5-Phosphorylated thiazoles containing either a formamidine fragment or an amino group were obtained. Some properties of the compounds synthesized were studied.

TRANSFORMATION OF N-HETEROARYLFORMAMIDINES. A NOVEL SYNTHESIS OF IMIDAZO/2,1-b/THIAZOLE AND IMIDAZO/2,1-b//1,3,4/THIADIAZOLE DERIVATIVES

Substituted imidazo/2,1-b/thiazole and imidazo/2,1-b//1,3,4/thiadiazole derivatives 3 and 9 were prepared from the corresponding thiazolylformamidine 2 by quaternization with phenacyl bromide and from the corresponding quaternized amino substituted 1,3,4-