188781-10-4

Usage

Uses

Used in Pharmaceutical Research and Development:
5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl(9CI) is used as a precursor in the synthesis of various pharmaceutical compounds due to its potential pharmacological properties. It is valued for its potential as an anti-inflammatory and anti-cancer agent, making it a promising candidate for the development of new therapeutics.
Used in Anti-inflammatory Applications:
In the medical field, 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl(9CI) is utilized as an anti-inflammatory agent, helping to reduce inflammation and associated symptoms. Its anti-inflammatory properties make it a candidate for the treatment of various inflammatory conditions.
Used in Anti-cancer Applications:
5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl(9CI) is also used as an anti-cancer agent, where it may contribute to the development of novel cancer therapies. Its potential to target and inhibit the growth of cancer cells is currently under investigation.
Used in Antimicrobial and Antiviral Applications:
5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl(9CI) is employed in the development of antimicrobial and antiviral agents, given its ability to combat microbial and viral infections. Its broad-spectrum activity makes it a candidate for use in various healthcare and pharmaceutical applications.
Used in Agrochemical Development:
5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl(9CI) is used in the development of agrochemicals, where it may serve as an active ingredient in pesticides or fungicides, contributing to crop protection and yield enhancement.
Used in Specialty Chemicals:
In the chemical industry, 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl(9CI) may also find applications in the development of specialty chemicals, where its unique properties can be leveraged for specific technical or industrial processes.

Upstream product

• 6319-01-3 ethyl 2-acetyl-3-ureido-2-propenoate 
• 188781-08-0 2-chloro-4-methylpyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 188781-13-7 2-chloro-4-methylpyrimidine-5-carbonyl chloride 

Relevant academic research and scientific papers

HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS

Heteroaromatic carboxamides of formula (I), wherein Y, R, and Ar are as defined in the description and the claims, and pharmaceutically acceptable salts thereof can be used in methods for the treatment of diseases which can be influenced by the inhibition of plasma kallikrein.

Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide].

We investigated the structure-activity relationship studies of N-[3, 5-bis(trifluoromethyl)phenyl][2-chloro-4-(trifluoromethyl)pyrimidin-5 -yl]carboxamide (1), an inhibitor of transcription mediated by both NF-kappaB and AP-1 transcription factors, with the goal of improving its potential oral bioavailability. Compounds were examined for cell-based activity, were fit to Lipinski's rule of 5, and were examined for potential gastrointestinal permeability using the intestinal epithelial cell line, Caco-2. Selected groups were substituted at the 2-, 4-, and 5-positions of the pyrimidine ring using solution-phase combinatorial methodology. The introduction of a fluorine in the place of 2-chlorine of 1 resulted in a compound with comparable activity. However, other substitutions at the 2-position resulted in a loss of activity. The trifluoromethyl group at the 4-position could be replaced with a methyl, ethyl, chlorine, or phenyl without a substantial loss of activity. The carboxamide group at the 5-position is critical for activity. If it was moved to the 6-position, the activity was lost. The 2-methyl analogue of 1 (81) showed comparable in vitro activity and improved Caco-2 permeability compared to 1.

Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions

Compounds having utility as anti-inflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine-containing compounds and, in one embodiment, are esters of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.

Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions

Compounds having utility as antinflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine- or pyrazine-containing compounds and, in one embodiment, are carboxyamides of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.