188781-10-4

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI)
• Synonyms: 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI);4-ethyl-2-hydroxy-pyrimidine-5-carboxylic acid;5-Carboxy-2-chloro-4-methylpyrimidine;5-Carboxy-2-chloro-4-methylpyrimidine, 2-Chloro-4-methyl-1,3-diazine-5-carboxylic acid;2-chloro-4-methyl-5-Pyrimidine carboxylic acid
• CAS NO: 188781-10-4
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.5691
• Product Categories: PYRIMIDINE;Building Blocks
• Mol File: 188781-10-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 375.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.479±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.06±0.25(Predicted)
• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI)(188781-10-4)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI)(188781-10-4)

Safety Data

• Hazardous Substances Data: 188781-10-4(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI) is a chemical compound with the molecular formula C6H5ClN2O2. It is a derivative of 2-chloro-4-methylpyrimidine and has a pyrimidine ring with a carboxylic acid functional group and a methyl and chlorine substituent. 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI) is commonly used in pharmaceutical research and development due to its potential pharmacological properties. It has been studied for its potential as an anti-inflammatory and anti-cancer agent, as well as for its antimicrobial and antiviral properties. Additionally, it may also have applications in the development of agrochemicals and other specialty chemicals.

Upstream product

• 6319-01-3 ethyl 2-acetyl-3-ureido-2-propenoate 
• 188781-08-0 2-chloro-4-methylpyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 188781-13-7 2-chloro-4-methylpyrimidine-5-carbonyl chloride 

Relevant articles and documents

HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS

Heteroaromatic carboxamides of formula (I), wherein Y, R, and Ar are as defined in the description and the claims, and pharmaceutically acceptable salts thereof can be used in methods for the treatment of diseases which can be influenced by the inhibition of plasma kallikrein.

Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions

Compounds having utility as anti-inflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine-containing compounds and, in one embodiment, are esters of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.