6319-01-3

Basic information

• Product Name: ethyl 2-[(carbamoylamino)methylidene]-3-oxobutanoate
• CAS NO: 6319-01-3
• Molecular Formula: C₈H₁₂N₂O₄
• Molecular Weight: 200.1919
• Mol File: 6319-01-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 306.2°C at 760 mmHg
• Flash Point: 139°C
• Density: 1.219g/cm³
• Vapor Pressure: 0.000785mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: ethyl 2-[(carbamoylamino)methylidene]-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(carbamoylamino)methylidene]-3-oxobutanoate(6319-01-3)
• EPA Substance Registry System: ethyl 2-[(carbamoylamino)methylidene]-3-oxobutanoate(6319-01-3)

Safety Data

• Hazardous Substances Data: 6319-01-3(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 149-73-5 trimethyl orthoformate 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 6214-65-9 5-acetyluracil 
• 6214-64-8 ethyl 4-methyl-2-oxo-1H-pyrimidine-5-carboxylate 
• 13008-17-8 4-methyl-2-oxo-1H-pyrimidine-5-carboxylic acid 
• 15231-48-8 4-methyl-1H-pyrimidin-2-one 
• 188781-10-4 2-chloro-4-methyl-pyrimidine-5-carboxylic acid 
• 188781-13-7 2-chloro-4-methylpyrimidine-5-carbonyl chloride 
• 188781-08-0 2-chloro-4-methylpyrimidine-5-carboxylic acid ethyl ester 
• 66373-46-4 2-hydrazino-4-methyl-pyrimidine-5-carboxylic acid ethyl ester 
• 6214-64-8 ethyl 2-hydroxy-4-methylpyrimidine-5-carboxylate 
• 875296-12-1 4-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2,4-dioxo-butyric acid methyl ester 
• 903594-07-0 1,3-bis(2-fluorobenzyl)-5-acetyluracil 
• 903594-08-1 1,3-bis(4-fluorobenzyl)-5-acetyluracil 
• 875296-11-0 5-acetyl-1,3-dibenzyluracil 

Relevant articles and documents

An improved procedure of Miyashita protocol for the preparation of ureidomethylene derivatives of 1,3-dicarbonyl compounds

A facile method has been developed for the synthesis of ureidomethylene derivatives by the condensation of 1,3-dicarbonyl compounds, urea and trimethylorthoformate in presence of Zn(OTf)2 under solvent-free conditions. A variety of 1,3-dicarbon

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate: An inhibitor of AP-1 and NF-κB mediated gene expression

Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-κB mediated transcriptional activation in Jurkat T cells. From our SAR work, ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))-N-methylamino]-4-(trifluoromethyl)- pyrimidine-5-carboxylate was identified as a novel and potent inhibitor.