188782-91-4

Upstream product

• 100-61-8 N-methylaniline 
• 188782-90-3 3-[2-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-propionyl chloride 
• 20921-02-2 7-methoxy-3,4-dihydro-2H-1-benzopyran-2-one 
• 21144-17-2 3-(2'-hydroxy-4'-methoxyphenyl)propanoic acid 
• 188782-89-0 t-butyldimethylsilyl 3-(2'-t-butyldimethylsilyloxy-4'-methoxyphenyl)propanoate 

Downstream Products

• 69471-28-9 methyl 3-(2'-hydroxy-4'-methoxyphenyl)propanoate 

Relevant academic research and scientific papers

Conversion of 7-Methoxy-3,4-dihydro-2H-1-benzopyran-2-one into the corresponding dimethyl ortho ester

7-Methoxy-3,4-dihydro-2H-1-benzopyran-2-one 2 was converted into 3-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-N-methyl-N-phenylpropanamide 25 and reaction of this with methyl trifluoromethanesulfonate, followed by reaction with sodium methoxide, gave 2,2,7-trimethoxy-2H- 1-benzopyran 1a in 55% overall yield from 25. A similar methylation/methoxide sequence using 3-(2'-benzyloxy-4-methoxyphenyl)-N-methyl-N-phenylpropanamide 18 gave a mixture which contained trimethyl 3-(2'-benzyloxy-4'-methoxyphenyl)orthopropanoate 20a and reaction of this mixture with a solution of sodium in tert-butanol gave a product in which 2,2,7-trimethoxy-2H-1-benzopyran 1a was detected, but not isolable.