188787-17-9Relevant academic research and scientific papers
Hypervalent iodine mediated para -selective fluorination of anilides
Tian, Tian,Zhong, Wen-He,Meng, Shuai,Meng, Xiang-Bao,Li, Zhong-Jun
, p. 728 - 732 (2013/02/25)
A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)2) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides.
Ortho lithiation of N-pivaloylfluoroanilines as a useful tool for either selective methylation or benzoxazole synthesis
Yoshida, Yasuo,Hamada, Yusuke,Umezu, Kazuto,Tabuchi, Fumiya
, p. 958 - 961 (2013/09/03)
Lithiation of N-pivaloyl-3,4-difluoroaniline (1a) with a slight excess of 2 mole equiv of n-butyllithium followed by methylation was studied. The reaction was found to be useful for either the selective methylation of 3,4-difluoroaniline or the synthesis of benzoxazole derivatives, depending on the reaction temperature. In the reaction of N-pivaloyl-3-chloro-4-fluoroaniline (1b) and N-pivaloyl-3-fluoroaniline (1c), the reaction proceeded rather sluggishly but benzoxazole formation predominated.
