188806-90-8

Basic information

• Product Name: ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(3R,5R)-2-(4-methoxy-benzyl)-3-thiazol-2-yl-isoxazolidin-5-yl]-methanone
• Synonyms: ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(3R,5R)-2-(4-methoxy-benzyl)-3-thiazol-2-yl-isoxazolidin-5-yl]-methanone
• CAS NO: 188806-90-8
• Molecular Weight: 517.67
• Mol File: 188806-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(3R,5R)-2-(4-methoxy-benzyl)-3-thiazol-2-yl-isoxazolidin-5-yl]-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(3R,5R)-2-(4-methoxy-benzyl)-3-thiazol-2-yl-isoxazolidin-5-yl]-methanone(188806-90-8)
• EPA Substance Registry System: ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(3R,5R)-2-(4-methoxy-benzyl)-3-thiazol-2-yl-isoxazolidin-5-yl]-methanone(188806-90-8)

Safety Data

• Hazardous Substances Data: 188806-90-8(Hazardous Substances Data)

Upstream product

• 51307-59-6 N-(4-methoxybenzyl)hydroxylamine 
• 94594-91-9 acrylcamphorsultam 
• 188806-18-0 N-(4-methoxybenzyl)-C-(2-thiazolyl)nitrone 

Downstream Products

• 188807-28-5 (3R,5R)-3-acetoxy-1-(4-methoxybenzyl)-5-(2-thiazolyl)-2-pyrrolidinone 
• 188807-18-3 (3R,5R)-3-hydroxy-1-(4-methoxybenzyl)-5-(2-thiazolyl)-2-pyrrolidinone 

Relevant articles and documents

1,3-dipolar cycloaddition of C-(2-thiazolyl)nitrones to chiral acrylates. Synthesis of enantiopure α-amino-2-alkylthiazoles and 5-formylpyrrolidin-2-ones

The 1,3-dipolar cycloaddition of thiazolyl nitrones with chiral acrylates has been studied. The use of the Oppolzer's camphor sultam as chiral inductor provided isoxazolidines with excellent regio- and diastereoselectivities and goad asymmetric induction. The cycloadducts were converted into homochiral α-amino-2-alkylthiazoles and 5-(2-thiazolyl)-3-hydroxy-2-pyrrolidinones. The latter compounds were precursors of highly functionalized pyrrolidines by the aldehyde unmasking from the thiazole ring and subsequent reactions of the formyl group.