188846-98-2

Basic information

• Product Name: 3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester
• Synonyms: 3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester;Benzyl 3-(tosyloxy)pyrrolidine-1-carboxylate;benzyl 3-(p-methylbenzenesulfonyloxy)pyrrolidine-1-carboxylate
• CAS NO: 188846-98-2
• Molecular Formula: C₁₉H₂₁NO₅S
• Molecular Weight: 375.43874
• Mol File: 188846-98-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester(188846-98-2)
• EPA Substance Registry System: 3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester(188846-98-2)

Safety Data

• Hazardous Substances Data: 188846-98-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester is used as a reagent in organic synthesis for the preparation of a variety of compounds. Its unique structure and functional groups contribute to the formation of complex molecules and the development of novel chemical entities.
Used in Peptide Synthesis as a Protecting Group:
In the pharmaceutical and biotechnology industries, 3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester is used as a protecting group in peptide synthesis. The benzyl ester group can be selectively removed under specific conditions, allowing for the controlled formation of peptide bonds and the synthesis of desired peptide sequences.
Used in Nucleophilic Substitution Reactions:
3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid benzyl ester is utilized in nucleophilic substitution reactions due to the toluene-4-sulfonyloxy group's ability to act as a good leaving group. This property makes the compound suitable for various chemical transformations, enabling the synthesis of new compounds and the modification of existing ones.

Upstream product

• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 188846-99-3 (+/-)-3-cyanopyrrolidine-1-carboxylic acid benzyl ester 
• 169750-16-7 benzyl 3-fluoropyrrolidine-1-carboxylate 

Relevant articles and documents

FUSED BENZENE DERIVATIVE AND USE

The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.

Non-classical antifolates

Compounds of the formula: in which:, Q is -OH or -NH2;, A is -CH2-, -CH2CH2-, -O-, or -S-;, -Ar- is a divalent aromatic ring;, W is -CO- or -SO2; and, Z is: (A) an α-amino acid group of the formula (B