188863-55-0

Upstream product

• 53087-13-1 3-(benzyloxy)phenyl bromide 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 36281-96-6 <3-(benzyloxy)phenyl>magnesium bromide 

Downstream Products

• 1370256-40-8 C₁₈H₁₉NO*ClH 
• 1370256-39-5 1-benzyl-4-(3-hydoxyphenyl)-1,2,3,6-tetrahydropyridine 
• 1370256-42-0 4-(3-hydroxyphenyl)piperidinium chloride 
• 325808-45-5 ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate 
• 325808-46-6 ethyl 2-[3-[1-(4-fluorobenzoyl)-1,2,3,6-tetrahydropyridin-4-yl]phenoxy]-2-methylpropanoate 
• 150664-50-9 1-[(4-chlorophenyl)sulfonyl]-4-hydroxy-4-(3-hydroxyphenyl)piperidine 
• 325808-15-9 1-(4-chlorobenzoyl)-4-hydroxy-4-(3-hydroxyphenyl)piperidine 
• 325808-16-0 1-(4-fluorobenzoyl)-4-hydroxy-4-(3-hydroxyphenyl)piperidine 
• 336882-06-5 acetic acid 2-{3-[1-(3-dimethylcarbamoyl-3,3-diphenyl-propyl)-4-hydroxy-piperidin-4-yl]-phenoxy}-ethyl ester 
• 336882-18-9 4-{4-hydroxy-4-[3-(2-hydroxy-ethoxy)-phenyl]-piperidin-1-yl}-N,N-dimethyl-2,2-diphenyl-butyramide 
• 336881-92-6 N,N-dimethyl-2,2-diphenyl-4-[4-hydroxy-4-(3-hydroxyphenyl)piperidin-1-yl]butanamide 
• 325808-14-8 4-hydroxy-4-(3-hydroxyphenyl)piperidine 

Relevant academic research and scientific papers

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.

New μ-opioid receptor agonists with phenoxyacetic acid moiety

New μ-opioid receptor (MOR) agonists containing 4-hydroxypiperidine, piperidine and piperazine moieties were synthesized and evaluated to find a peripheral opioid analgesic. Among the synthesized compounds, [2-[1-[3-(N,N-dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxypiperidin-4-yl] phenoxy]acetic acid (8: SS620) having phenoxyacetic acid and 4-hydroxypiperidine moieties showed the highest agonist potency on the MOR in an isolated guinea-pig ileum preparation, and it also had selectivity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells compared with the same types of δ- and κ-opioid receptors (DOR and KOR). In addition, compound 8 showed a 10 times more potent MOR agonist activity than loperamide. Furthermore, compound 8 showed a peripheral analgesic activity in vivo screening on rat.

New strong fibrates with piperidine moiety

New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxy]-2-methylpropanoic acid (9