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CAS

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188869-24-1

(RS)-[1-benzyl-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridin-3-yl]-methanol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 188869-24-1 Structure

  • Basic information

    1. Product Name: (RS)-[1-benzyl-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridin-3-yl]-methanol
    2. Synonyms:
    3. CAS NO:188869-24-1
    4. Molecular Formula:
    5. Molecular Weight: 297.372
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 188869-24-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (RS)-[1-benzyl-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridin-3-yl]-methanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: (RS)-[1-benzyl-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridin-3-yl]-methanol(188869-24-1)
    11. EPA Substance Registry System: (RS)-[1-benzyl-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridin-3-yl]-methanol(188869-24-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 188869-24-1(Hazardous Substances Data)

188869-24-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 188869-24-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,8,6 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 188869-24:
(8*1)+(7*8)+(6*8)+(5*8)+(4*6)+(3*9)+(2*2)+(1*4)=211
211 % 10 = 1
So 188869-24-1 is a valid CAS Registry Number.

188869-24-1Relevant articles and documents

Procee for the racemisation of 1-benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-1,2-3,6-tetrahydropyridine to be used as intermediate in the synthesis of paroxetine

-

, (2008/06/13)

A process for the racemisation of enantiomerically enriched 1-benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-1,2,3,6-tetrahydropyridine which is a useful intermediate in the preparation of paroxetine. Formula (A) means that the compound (I) has an enantiomeric excess of one enantiomer over the other enantiomer. R1 and R2 are defined as in claim 1.

A convenient synthesis of (-)-paroxetine

Czibula, Laszlo,Nemes, Andras,Seboek, Ferenc,Szantay Jr., Csaba,Mak, Marianna

, p. 3336 - 3339 (2007/10/03)

A convenient synthesis of the antidepressant paroxetine starting from 1-benzyl-4-piperidone (2) is reported. A stereoselective reduction resulted in cis-piperidine-3-methanol [(+)-6]. The reaction between cis-piperidine-3- methanol mesylate (7) and sesamol led to benzyl-protected trans-paroxetine (9) through an inversion reaction of the stereogenic center at position 3. The latter compound was deprotected by hydrogenolysis. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Piperidine derivatives having renin inhibiting activity

-

, (2008/06/13)

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.

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