163630-89-5

Basic information

• Product Name: 1-BENZYL-4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE
• Synonyms: Paroxetine Impurity 56;Pyridine, 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)-
• CAS NO: 163630-89-5
• Molecular Formula: C₁₈H₁₈FN
• Molecular Weight: 267.34
• Mol File: 163630-89-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE(163630-89-5)
• EPA Substance Registry System: 1-BENZYL-4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE(163630-89-5)

Safety Data

• Hazardous Substances Data: 163630-89-5(Hazardous Substances Data)

Upstream product

• 1978-59-2 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine 
• 100-39-0 benzyl bromide 
• 50-00-0 formaldehyd 
• 1765-93-1 4-fluoroboronic acid 
• 107301-61-1 N-benzyl-4-amino-1-butyne 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 352-13-6 4-flourophenylmagnesium bromide 
• 1978-61-6 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride 
• 39795-58-9 4-(4-fluorophenyl)pyridine 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 41979-39-9 4-piperidone hydrochloride 
• 330173-08-5 N-benzyl-2-(4-methylphenylsulfonyl)acetamide 
• 936231-01-5 1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine hydrochloride 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 163630-90-8 4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 188869-24-1 (RS)-[1-benzyl-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridin-3-yl]-methanol 
• 748183-39-3 6-(4-fluorophenyl)-3-azabicyclo[4.1.0]heptane 
• 143682-41-1 3-{4-[4-(4-fluorophenyl)-1-(1,2,3,6-tetrahydro)pyridinyl]-1-butyl}-1H-indole 
• 1978-59-2 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine 
• 640722-77-6 1-(benzyl)-4-(p-fluorophenyl)piperidin-2-one 
• 37656-48-7 4-(4-fluorophenyl)piperidine 

Relevant articles and documents

Transition-Metal-Free Deconstructive Lactamization of Piperidines

One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)–C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)–H oxidation, as transitory intermediates. Experimental and theoretical studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer–Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramolecular translactamization.

Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors

With the aim of obtaining compounds possessing high SERT selectivity, in the present work we synthesized and studied the inhibition of serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters by docking studies and experimental binding measu

SYNTHESIS OF UNSATURATED PIPERIDINES FROM PIPERIDONES WITH A SILYL REAGENT

Syntheses of unsaturated piperidines from piperidones through a silyl pipehdine reagent via the Shapiro reaction and palladium-catalyzed cross- coupling reactions with organo halides.