188871-69-4

Upstream product

• 209973-99-9 2-benzyloxy-5-iodopyridine 
• 14233-64-8 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one 
• 83664-33-9 2-(benzyloxy)-5-bromopyridine 

Relevant academic research and scientific papers

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Synthesis of 5-(β-D-ribofuranosyl)-pyridin-2-one: A 'deletion-modified' analogue of uridine

Pyridin-2-one C-nucleoside 2 was prepared using several different approaches. The most efficient pathway utilized the condensation of 2,3,5-tri-O-benzyl-D-ribono-1,4-lactone (4) and 2-(benzyloxy)-5-bromopyridine (5), followed by deoxygenation with Et3SiH/BF3·Et2O and removal of the benzyl protecting groups.