188874-86-4

Upstream product

• 13314-69-7 1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine 

Downstream Products

• 188874-42-2 (3R,4S,5S)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-3,5-dihydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 188874-91-1 (3R,4S,5S)-3,5-Dihydroxy-4-(4-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 188874-90-0 (3R,4S,5S)-4-(4-Hydroxy-phenyl)-piperidine-3,5-diol 
• 188874-87-5 (RS)-1-benzyl-3-ethoxy-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

Piperidine derivatives having renin inhibiting activity

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.

Piperidine-renin inhibitors compounds with improved physicochemical properties

Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D((pH 7.4)) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.