188874-91-1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 188874-90-0 (3R,4S,5S)-4-(4-Hydroxy-phenyl)-piperidine-3,5-diol 
• 188874-86-4 RS)-1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridin-3-ol 
• 188874-87-5 (RS)-1-benzyl-3-ethoxy-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine 
• 13314-69-7 1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine 

Downstream Products

• 188874-42-2 (3R,4S,5S)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-3,5-dihydroxy-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Piperidine-renin inhibitors compounds with improved physicochemical properties

Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D((pH 7.4)) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.