188889-27-2

Basic information

• Product Name: Benzoic acid, 4-[(3,4-dihydro-4-oxo-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester
• CAS NO: 188889-27-2
• Molecular Formula: C20H16O3S
• Molecular Weight: 336.411
• Mol File: 188889-27-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(3,4-dihydro-4-oxo-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(3,4-dihydro-4-oxo-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester(188889-27-2)
• EPA Substance Registry System: Benzoic acid, 4-[(3,4-dihydro-4-oxo-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester(188889-27-2)

Safety Data

• Hazardous Substances Data: 188889-27-2(Hazardous Substances Data)

Upstream product

• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 188889-25-0 6-ethynyl-thiochroman-4-one 
• 188889-23-8 6-(trimethylsilylethynyl)-thiochroman-4-one 
• 106-53-6 para-bromobenzenethiol 
• 13735-04-1 3-(4-Bromophenylsulfanyl)propanoic Acid 
• 13735-13-2 6-bromo-2,3-dihydro-4H-1-benzothiopyran4-one 

Downstream Products

• 244241-10-9 ethyl 4-<(4-(4-(1,1-dimethylethyl)phenyl)-(2H)-thiochromen-6-yl)ethynyl>benzoate 
• 244241-08-5 ethyl 4-<(4-(4-ethylphenyl)-(2H)-thiochromen-6-yl)ethynyl>benzoate 
• 244241-09-6 ethyl 4-<(4-(4-(1-methylethyl)phenyl)-(2H)-thiochromen-6-yl)ethynyl>benzoate 
• 188888-61-1 ethyl 4-<(4-(4-methylphenyl)-(2H)-thiochromen-6-yl)ethynyl>benzoate 
• 244241-07-4 ethyl 4-<(4-phenyl-(2H)-thiochromen-6-yl)ethynyl>benzoate 
• 188889-29-4 ethyl 4-<(4-trifluorosulfonyloxy-(2H)-thiochromen-6-yl)ethynyl>benzoate 

Relevant articles and documents

Synthesis and biological activity of high-affinity retinoic acid receptor antagonists

This article reports the synthesis and biological activity of new high affinity retinioic acid receptor (RAR) antagonists. The effect of introducing heteroatoms in the bicyclic ring system of the potent dihydronaphthalene RAR antagonist 8, and the variation of the pendant aromatic group on the ability of these compounds to function as RAR antagonists is discussed. The use of binding, transcriptional, and in vivo assays revealed that the 2,2-dimethylthiochromene analogue 59, and the 2,2-dimethylchromene derivative 85, were the most effective in blocking retinoid agonist induced activity. Copyright (C) 1999 Elsevier Science Ltd.