1889-64-1Relevant academic research and scientific papers
Copper promoted: N -alkylation of sulfoximines with alkylboronic acid under mild conditions
Gupta, Surabhi,Chaudhary, Priyanka,Muniyappan, Nalluchamy,Sabiah, Shahulhameed,Kandasamy, Jeyakumar
supporting information, p. 8493 - 8498 (2017/10/27)
The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids. In addition, N-methylation and cyclopropylation of the bioactive l-methionine sulfoximine derivative was demonstrated under standard reaction conditions.
Metal-Free, Phosphonium Salt-Mediated Sulfoximination of Azine N-Oxides: Approach for the Synthesis of N-Azine Sulfoximines
Aithagani, Sravan Kumar,Kumar, Mukesh,Yadav, Mahipal,Vishwakarma, Ram A.,Singh, Parvinder Pal
, p. 5886 - 5894 (2016/07/23)
Herein, we report a simple and metal-free method for the synthesis of N-azine sulfoximines by the nucleophilic substitution of azine N-oxides with NH-sulfoximines. The present method works at room temperature with wide functional group compatibility and gives several unprecedented N-azine sulfoximines. The reaction conditions were also found suitable with enantiopure substrates and furnished products without any racemization. It also finds an application in the sulfoximination of azine-based functional molecules such as 2,2′-bipyridine, 1,10-phenanthroline, and quinine.
Metal-Free Approach for the Synthesis of N-Aryl Sulfoximines via Aryne Intermediate
Aithagani, Sravan Kumar,Dara, Saidulu,Munagala, Gurunadham,Aruri, Hariprasad,Yadav, Mahipal,Sharma, Shweta,Vishwakarma, Ram A.,Singh, Parvinder Pal
, p. 5547 - 5549 (2015/12/01)
A metal-free and operationally simple N-arylation of NH-sulfoximines with aryne precursors is reported. Transition metal-free reaction conditions and shorter reaction times are the highlights of the present method. The mild optimized condition was also found to be suitable with enantiopure substrates.
Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides
Miao, Jinmin,Richards, Nigel G. J.,Ge, Haibo
supporting information, p. 9687 - 9689 (2014/08/18)
A novel rhodium-catalyzed imination of sulfoxides using O-(2,4-dinitrophenyl)hydroxylamine is developed under mild conditions with good functional group tolerance. This method provides an efficient access to free NH-sulfoximines, an important structural u
