188907-61-1

Upstream product

• 181868-33-7 (1'R,4'S)-4'-benzoyloxy-1'-(6-chloro-9H-purin-9-yl)cyclopent-2'-ene 
• 87-42-3 6-chloropurine 
• 4157-02-2 cis 2-cyclopentene 1,4-dibenzoate 
• 21272-85-5 phenylsulfonylnitromethane 
• 188907-60-0 (1'R,4'S)-1'-(6-chloropurin-9-yl)-4'-phenylsulfonyl(nitro)methyl-cyclopent-2'-ene 

Downstream Products

• 156407-85-1 2',3'-diepi-neplanocin 
• 188907-68-8 (3'R,4'R)-4'-(6-chloropurin-9-yl)-1'-methoxycarbonyl-3'-(p-nitrobenzoyl)oxy-cyclopent-1'-ene 
• 72877-50-0 neplanocin A 

Relevant academic research and scientific papers

An enantio- and diastereo-controlled synthesis of (-)neplanocin A and its 2,3-di-epi isomer

An enantioselective Pd catalyzed desymmetrization of cis-3,5-dibenzoyloxycyclopent-2-ene combined with a diastereoselective epoxidation provided a common intermediate that can bifurcate to form either (-)-neplanocin A or its 2,3-di-epi isomer.

Palladium-catalyzed enantioselective synthesis of carbanucleosides

A general strategy has been developed for enantioselective synthesis of diverse carbanucleosides. The key step is a Pd(0)-catalyzed enantioselective allylic amination of cis-3,5-dibenzoyloxycyclopent-2-ene 10a with the nucleobase. With guanine-derived nuc