188936-99-4

Upstream product

• 616-02-4 citraconic acid anhydride 
• 139438-53-2 ethyl 4-hydrazino-2-phenylpyrimidine-5-carboxylate 
• 618-39-3 benzamidin 
• 55613-22-4 4-hydroxy-2-phenyl-5-pyrimidinecarboxylic acid ethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 24755-82-6 ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Novel inhibitors of AP-1 and NF-κB mediated gene expression: Structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate

In an effort to identify novel inhibitors of AP-1 and NF-κB mediated transcriptional activation, several analogues of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate (1) were synthesized and tested in two in vitro assays. The 2-(2'-thienyl) substituted compound (11) was identified as the most potent in this series. (C) 2000 Elsevier Science Ltd. All rights reserved.