55613-22-4

Basic information

• Product Name: ETHYL 6-OXO-2-PHENYL-1,6-DIHYDRO-5-PYRIMIDINECARBOXYLATE
• Synonyms: ETHYL 6-OXO-2-PHENYL-1,6-DIHYDRO-5-PYRIMIDINECARBOXYLATE;Ethyl 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylate;5-(Ethoxycarbonyl)-2-phenylpyrimidin-4(3H)-one;4-Hydroxy-2-phenylpyrimidine-5-carboxylic acid ethyl ester;Ethyl 3,4-dihydro-4-oxo-2-phenylpyrimidine-5-carboxylate;Ethyl 6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate
• CAS NO: 55613-22-4
• Molecular Formula: C₁₃H₁₂N₂O₃
• Molecular Weight: 244.25
• Mol File: 55613-22-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 209-212°
• Boiling Point: 309.1°Cat760mmHg
• Flash Point: 140.7°C
• Appearance: /
• Density: 1.25
• Vapor Pressure: 0.000358mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 6-OXO-2-PHENYL-1,6-DIHYDRO-5-PYRIMIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 6-OXO-2-PHENYL-1,6-DIHYDRO-5-PYRIMIDINECARBOXYLATE(55613-22-4)
• EPA Substance Registry System: ETHYL 6-OXO-2-PHENYL-1,6-DIHYDRO-5-PYRIMIDINECARBOXYLATE(55613-22-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 55613-22-4(Hazardous Substances Data)

Usage

General Description

"Ethyl 6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarboxylate" is a specific chemical compound, mostly known for its application in synthesizing pharmaceutically valuable compounds. Due to its complex structure, it is widely used in the field of medicinal chemistry and drug development. This pyrimidine derivative contains an aromatic phenyl ring and an ester group, which may contribute to its reactivity in chemical reactions. However, its exact properties like toxicity, solubility, melting point or boiling point are not specifically documented yet, underlining the need for further investigation and study into its properties and potential applications.

InChI:InChI=1/C13H12N2O3/c1-2-18-13(17)10-8-14-11(15-12(10)16)9-6-4-3-5-7-9/h3-8H,2H2,1H3,(H,14,15,16)

Upstream product

• 618-39-3 benzamidin 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1670-14-0 benzamidine monohydrochloride 
• 38026-46-9 ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxilate 
• 960-16-7 tributylphenylstannane 
• 49597-05-9 propene-1,1,3,3-tetracarboxylic acid tetraethyl ester 
• 613-92-3 N-hydroxybenzenecarboximidamide 

Downstream Products

• 1150622-76-6 FAC 
• 433710-00-0 N-benzyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide 
• 433709-98-9 N-benzyl-2-(8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide 
• 1149758-76-8 4-((2-(benzylamino)-2-oxoethyl)amino)-2-phenylpyrimidine-5-carboxylic acid 
• 1149758-75-7 ethyl 4-((2-(benzylamino)-2-oxoethyl)amino)-2-phenylpyrimidine-5-carboxylate 
• 226954-91-2 2-(5-ethoxycarbonyl-2-phenylpyrimidine-4-ylamino)acetic acid 

Relevant articles and documents

Design and synthesis of phenoxypyridyl acetamide or aryl-oxodihydropurine derivatives for the development of novel pet ligands targeting the translocator protein 18 kDa (TSPO)

-

Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives

Herein we describe NMR experiments and structural modifications of 4-methyl-2-phenylpyrimidine-N-acylhydrazone compounds (aryl-NAH) in order to discover if duplication of some signals in their 1H- and 13C-NMR spectra was related to a mixture of imine double bond stereoisomers (E/Z) or CO-NH bond conformers (syn and anti-periplanar). NMR data from NOEdiff, 2D-NOESY and 1H-NMR spectra at different temperatures, and also the synthesis of isopropylidene hydrazone revealed the nature of duplicated signals of a 4-methyl-2-phenylpyrimidine-N-acylhydrazone derivative as a mixture of two conformers in solution. Further we investigated the stereoelectronic influence of substituents at the ortho position on the pyrimidine ring with respect to the carbonyl group, as well as the electronic effects of pyrimidine by changing it to phenyl. The conformer equilibrium was attributed to the decoplanarization of the aromatic ring and carbonyl group (generated by an ortho-alkyl group) and/or the electron withdrawing character of the pyrimidine ring. Both effects increased the rotational barrier of the C-N amide bond, as verified by the ΔG≠ values calculated from dynamic NMR. As far as we know, it is the first description of aryl-NAH compounds presenting two CO-NH bond-related conformations.

AMIDE COMPOUNDS AND USE OF THE SAME

A renin inhibitor comprising a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof. The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like