Tetrahedron Letters p. 1073 - 1076 (1996)
Update date:2022-08-04
Topics:
Toshima, Kazunobu
Yamaguchi, Hiroyuki
Jyojima, Takaaki
Noguchi, Yasunobu
Nakata, Masaya
Matsumura, Shuichi
The total synthesis of the macrolide antibiotic, bafilomycin A1 (1), has been achieved by a convergent route involving aldol condensation between the 16-membered lactonic aldehyde 2 and the ethyl ketone 3, followed by desilylation.
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