Total synthesis of bafilomycin A1. 2. The assemblage and completion of the synthesis

DOI: 10.1016/0040-4039(95)02351-8

Source and publish data:

Tetrahedron Letters p. 1073 - 1076 (1996)

Update date:2022-08-04

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Authors:

Toshima, Kazunobu

Yamaguchi, Hiroyuki

Jyojima, Takaaki

Noguchi, Yasunobu

Nakata, Masaya

Matsumura, Shuichi

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Article abstract of DOI:10.1016/0040-4039(95)02351-8

The total synthesis of the macrolide antibiotic, bafilomycin A₁ (1), has been achieved by a convergent route involving aldol condensation between the 16-membered lactonic aldehyde 2 and the ethyl ketone 3, followed by desilylation.

Full text of DOI:10.1016/0040-4039(95)02351-8

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