Total synthesis of bafilomycin A1. 2. The assemblage and completion of the synthesis

Article abstract of DOI:10.1016/0040-4039(95)02351-8

The total synthesis of the macrolide antibiotic, bafilomycin A₁ (1), has been achieved by a convergent route involving aldol condensation between the 16-membered lactonic aldehyde 2 and the ethyl ketone 3, followed by desilylation.