188940-48-9

Upstream product

• 188940-43-4 [5-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-(3-methoxy-phenylsulfanyl)-isoxazol-3-yl]-carbamic acid tert-butyl ester 
• 188940-45-6 acetic acid 3-[3-tert-butoxycarbonylamino-4-(3-methoxy-phenylsulfanyl)-isoxazol-5-yl]-propyl ester 
• 188940-44-5 [5-(3-hydroxy-propyl)-4-(3-methoxy-phenylsulfanyl)-isoxazol-3-yl]-carbamic acid tert-butyl ester 
• 188940-46-7 acetic acid 3-[3-amino-4-(3-methoxy-phenylsulfanyl)-isoxazol-5-yl]-propyl ester 
• 188940-61-6 5-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-isoxazole-3-carboxylic acid ethyl ester 
• 188940-62-7 5-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-isoxazole-3-carboxylic acid 
• 174078-93-4 {5-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-isoxazol-3-yl}-carbamic acid tert-butyl ester 
• 61362-77-4 5-[tert-butyldimethylsilyloxy]pent-1-yne 
• 15570-12-4 3-methoxybenzenethiol 
• 59014-89-0 bis(3-methoxyphenyl)disulfide 
• 5390-04-5 pent-1-yn-5-ol 

Downstream Products

• 302957-80-8 4-[3-(4-tert-butyl-benzenesulfonylamino)-4-(3-methoxy-phenylsulfanyl)-isoxazol-5-yl]-butyric acid 
• 302957-81-9 4-[3-(4-tert-butyl-benzenesulfonylamino)-4-(3-methoxy-phenylsulfanyl)-isoxazol-5-yl]-butyric acid methyl ester 
• 188940-39-8 4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide 
• 188940-50-3 4-tert-butyl-N-[5-(3-cyano-propyl)-4-(3-methoxy-phenylsulfanyl)-isoxazol-3-yl]-benzenesulfonamide 

Relevant academic research and scientific papers

Discovery and synthesis of a potent sulfonamide ET(B) selective antagonist

The synthesis and structure-activity relationships of a series of sulfonamide endothelin antagonists are described. In the course of our modification studies, we discovered ET(B) selective antagonists. The most potent compound 15f displays IC50 values of 1.7 μM and 0.002 μM to ET(A) and ET(B) receptors, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.