188943-73-9

Basic information

• Product Name: 2-(4-bromophenyl)pent-4-enoic acid
• Synonyms: 2-(4-bromophenyl)pent-4-enoic acid
• CAS NO: 188943-73-9
• Molecular Weight: 255.111
• Mol File: 188943-73-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)pent-4-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)pent-4-enoic acid(188943-73-9)
• EPA Substance Registry System: 2-(4-bromophenyl)pent-4-enoic acid(188943-73-9)

Safety Data

• Hazardous Substances Data: 188943-73-9(Hazardous Substances Data)

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 106-95-6 allyl bromide 
• 556-56-9 allyl iodid 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 362483-70-3 methyl 2-(4-bromophenyl)pent-4-enoate 

Downstream Products

• 301854-29-5 3-(4-bromophenyl)-5-methyltetrahydrofuran-2-one 
• 463936-46-1 C₁₁H₁₀BrClO 
• 591-80-0 pent-4-enoic acid 
• 362483-84-9 3-(4-bromo-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-dihydro-furan-2-one 
• 362483-88-3 3-(4-bromo-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-5H-furan-2-one 
• 362483-24-7 3-(4-bromophenyl)-5-hydroxymethyl-2,5-dihydrofuran-2-one 
• 362483-77-0 3-(4-bromo-phenyl)-5-hydroxymethyl-dihydro-furan-2-one 

Relevant articles and documents

Exploring the physicochemical and antiproliferative properties of biaryl-linked [13]-macrodilactones

A macrocyclic motif fosters productive protein-small molecule interactions. There are numerous examples of both natural product and designed, synthetic macrocycles that modulate the immune system, slow microbial infection, or kill eukaryotic cells. Reported here are the synthesis, physicochemical characterization, and antiproliferative activity of a group of [13]-macrodilactones decorated with a pendant biaryl moiety. Biaryl analogs were prepared by Suzuki reactions conducted on a common intermediate that contained a bromophenyl unit alpha to one of the carbonyls of the [13]-macrodilactone. Principal component analysis placed the new compounds in physicochemical context relative to a variety of pharmaceuticals and natural products. Modest inhibition of proliferation was observed in ASZ cells, a murine basal cell carcinoma line. This work underscores the value of an approach toward the identification of bioactive compounds that places the evaluation of physicochemical parameters early in the search process.

Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation

Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT2C receptor antagonists and the discovery of a new class of potent and selective 5-HT2C

5-AMIDOMETHYL ALPHA, BETHA-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS

The present invention provides for new 5-amidomethyl, alpha , beta -saturated and-unsaturated butyrolactone antibacterial agents of formula I I characterized by 3-aryl substituents that include, for example, indolinyl and phenyl substituted with z