188944-93-6Relevant academic research and scientific papers
Stereospecific coupling reaction for internucleotide methyl phosphonothioate linkage
Lebedev, Alexander V.,Rife, Jason P.,Seligsohn, Howard W.,Wenzinger, George R.,Wickstrom, Eric
, p. 855 - 858 (2007/10/02)
The (Sp)- and (Rp)- diastereomers of 5′-dimethoxytritylthymidyl-(3′-5′)methylphosphono-5′- thio-3′-acetylthymidine were prepared by the stereospecific reaction of 5′-deoxy-5′-iodo-3′-acetylthymidine with the (Sp)- or (Rp)- diastereomers of 5′-dimethoxytritylthymidyl-3′ methylphosphonothioate (Li+ salt) in DMF. At 50°C, the coupling reaction was complete within 6 hours.
