188945-54-2

Upstream product

• 169764-33-4 (2S,3R)-3-[Allyl-((R)-1-phenyl-ethyl)-amino]-2-((R)-1-hydroxy-ethyl)-pent-4-enoic acid tert-butyl ester 
• 169764-21-0 (S)-3-[Allyl-((R)-1-phenyl-ethyl)-amino]-pent-4-enoic acid tert-butyl ester 
• 16809-92-0 tert-butyl (2E)-penta-2,4-dienoate 
• 21651-12-7 (E)-2,4-pentadienoic acid 

Downstream Products

• 188945-52-0 (2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid 
• 188945-55-3 (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-((R)-1-phenyl-ethyl)-4-vinyl-azetidin-2-one 
• 188945-53-1 (3S,4R)-3-((R)-1-Hydroxy-ethyl)-1-((R)-1-phenyl-ethyl)-4-vinyl-azetidin-2-one 

Relevant academic research and scientific papers

Use of lithium (α-methylbenzyl)allylamide for a formal asymmetric synthesis of thienamycin

The highly stereoselective conjugate addition of lithium (αR)-(α-methylbenzyl)allylamide 3 to (E)-tert-butyl penta-2,4-dienoate 4, followed by a stereoselective aldol reaction with acetaldehyde, are the key steps in the synthesis of the known β-lactam int