188949-01-1Relevant articles and documents
An efficient stereoselective synthesis of 1α,24(R)-dihydroxyvitamin D3 by the dienyne route
Fall, Yagamare,Torneiro, Mercedes,Castedo, Luis,Mourino, Antonio
, p. 4703 - 4714 (2007/10/03)
1α,24(R)-Dihydroxyvitamin D3 (5e) was synthesized. The key step in the preparation of the side-chain was opening of the chiral epoxide 10 by the α-anion of the nitrile 9. The triene system was synthesized by the dienyne route.