66774-80-9Relevant articles and documents
Synthesis and biological evaluation of calcioic acid
Arnold, Leggy A.,Di Milo, Elliot S.,Mutchie, Tania R.,Yu, Olivia B.
, (2019/11/25)
Herein, we describe the synthesis of calcioic acid following a recently developed synthetic strategy for calcitroic acid. Several improvements to reaction conditions were made, which resulted in higher yields. The improved workup and isolation procedures
A protecting group-free synthesis of (-)-hortonones A-C from the Inhoffen-Lythgoe diol
Stambulyan, Hovsep,Minehan, Thomas G.
supporting information, p. 8728 - 8731 (2016/10/03)
A synthesis of hortonones A-C has been accomplished from vitamin D2via the Inhoffen-Lythgoe diol without the use of protective groups. Key steps in the syntheses include a TMS-diazomethane mediated regioselective homologation of the cyclohexano
Synthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3
Thomas, Emmanuel,Brion, Jean-Daniel,Peyrat, Jean-Fran?ois
, p. 381 - 393 (2014/11/07)
In an effort to develop novel vitamin D3 analogues, a series of aromatic compounds was synthetized, using efficient Negishi cross coupling between alkenylzinc reagents of the C,D-ring moiety of vitamin D3, and various substituted aromatic halides as A-ring mimics. The study aimed at exploring the influence of the replacement of the original vitamin D3 diene by a styrene unit on the biological activities. Potency in the induction of the differentiation of HL-60 cells for the lead compound 36 was 12 fold less important than calcitriol correlating with a weaker binding affinity for VDR.