188949-79-3Relevant academic research and scientific papers
Synthesis and conformational study of 3-hydroxy-4-(hydroxymethyl)-1-cyclohexanyl purines and pyrimidines
Maurinsh, Yuris,Schraml, Jan,De Winter, Hans,Blaton, Norbert,Peeters, Oswald,Lescrinier, Eveline,Rozenski, Jef,Van Aerschot, Arthur,De Clercq, Erik,Busson, Roger,Herdewijn, Piet
, p. 2861 - 2871 (2007/10/03)
The cyclohexane nucleosides with a 1,4-relationship between nucleoside base and hydroxymethyl moiety were synthesized using a conjugated addition reaction of the nucleobases to ethyl 1,3-cyclohexadiene-1-carboxylate and hydroboration of the cyclohexenyl precursor. The lack of antiviral activity of the compounds was correlated with the conformation of these nucleosides as deduced from NMR and X-ray analysis.
