188965-47-1

Basic information

• Product Name: 3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-
• CAS NO: 188965-47-1
• Molecular Formula: C19H30N2O4
• Molecular Weight: 350.458
• Mol File: 188965-47-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-(188965-47-1)
• EPA Substance Registry System: 3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-(188965-47-1)

Safety Data

• Hazardous Substances Data: 188965-47-1(Hazardous Substances Data)

Upstream product

• 622-30-0 N-benzyl hydroxylalmine 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 75-16-1 methylmagnesium bromide 
• 158723-45-6 (Z)-N-[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]benzylamine N-oxide 

Downstream Products

• 156174-47-9 (2R,3S)-3-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyric acid 
• 189024-55-3 (R)-4-((S)-1-Benzyloxycarbonylamino-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 168034-38-6 ((1S,2R)-2-tert-Butoxycarbonylamino-3-hydroxy-1-methyl-propyl)-carbamic acid benzyl ester 

Relevant articles and documents

Totally stereocontrolled synthesis of α,β-diamino acids by addition of grignard reagents to nitrones derived from L-serine

The asymmetric synthesis of protected (2R,3S)- and (2R,3R)-3-substituted 2,3-α-amino acids is reported. The key step in the synthesis of these compounds is the diastereoselective addition of Grignard reagents to α- amino nitrones derived from L-serine. Total stereocontrol of the addition step is achieved by changing the protecting groups in the starting material. The predominant selectivity in each case can be reasonably interpreted in terms of steric effects of the substituents.