188966-02-1Relevant articles and documents
Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase
Chen, Shoujun,Lin, Chun-Hung,Walsh, Christopher T.,Coward, James K.
, p. 505 - 510 (1997)
A phosphinate analog of glutathionyl spermidine (Gsp), 3, has been synthesized and evaluated as an inhibitor of Gsp synthetase (GSPS). In addition, a non-spermidine-containing derivative (4) was synthesized in order to evaluate the role of the polyamine m
Synthesis and biochemical studies of phosphorus-based "tetrahedral mimics" as inhibitors of ATP-dependent ligases
Coward, James K.
, p. 113 - 116 (2007/10/03)
The synthesis of several phosphapeptides and the biochemical evaluation of these compounds as inhibitors of glutathionylspermidine synthetase and folylpolyglutamate synthetase is described.
Investigations on New Strategies for the Facile Synthesis of Polyfunctionalized Phosphinates: Phosphinopeptide Analogues of Glutathionylspermidine
Chen, Shoujun,Coward, James K.
, p. 502 - 509 (2007/10/03)
Three possible methods for the facile synthesis of functionalized phosphinates, including the core of complex phosphinopeptide analogues of glutathionylspermidine, were explored. Among these methods, the three-component condensation reaction involving ben