188974-48-3

Basic information

• Product Name: (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide
• Synonyms: (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide
• CAS NO: 188974-48-3
• Molecular Weight: 333.363
• Mol File: 188974-48-3.mol

Chemical Properties

• CAS DataBase Reference: (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide(188974-48-3)
• EPA Substance Registry System: (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide(188974-48-3)

Safety Data

• Hazardous Substances Data: 188974-48-3(Hazardous Substances Data)

Upstream product

• 195816-25-2 (5R)-3-(4-(1-Benzyl-1,2,5,6-tetrahydropyridin-4-yl)-3-fluorophenyl)-5-hydroxymethyl-oxazolidin-2-one 
• 371195-46-9 (R)-N-{3-[3-fluoro-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-2-oxooxazolidin-5-yl-methyl}azide 
• 188975-28-2 (S)-(-)-4-[4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]-3,6-dihydro-1(2H)-pyridinecarboxylic acid 1,1-dimethylethyl ester 
• 195816-24-1 (S)-N-{3-[3-fluoro-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-2-oxooxazolidin-5-yl-methyl}acetamide 

Relevant articles and documents

OXAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS

The present invention provides novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmac

OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS

The present invention relates to certain substituted phenyl oxazolidinones of formula (I) or (II) and to the processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invent

Antibiotic oxazolidinone derivatives

The invention concerns a compound of the formula (I): wherein, for example: R1is of the formula —NHC(═O)Rbwherein Rbis, for example, (1-4C)alkyl; R2and R3are hydrogen or fluoro; R2and R3are hydrogen or fluoro; D is O; R4and R5are hydrogen, (1-4C)alkyl or AR-oxymethyl; AR is phenyl or phenyl(1-4C)alkyl; R6is hydrogen; >A—B— is of the formula >C═C(Ra)—, >CHCHRa—, or >C(OH)CHRa— (> represents two single bonds) wherein Rais hydrogen or (1-4C)alkyl; and pharmaceutically-acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.

Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings

A compound of the formula (I): STR1 or pharmaceutical acceptable salts thereof wherein X is NR1, S(O)g, or O; R1 is H, C1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R1 is --(CH2)h -- aryl, --COR1--1, --COOR1-2, --CO--(CH2)h --COR1--1, C1-6 alkyl sulfonyl, --SO2 --(CH2)h --aryl, or --(CO)i --Het; R2 is H, C1-6 alkyl, --(CH2)h --aryl, or halo; R3 and R4 are the same or different and are H or halo; R5 is H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.